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目的 Acutelunginjury(ALI)hasahighlethalityof40%,accountingforaround75,000deathsperyearinUSA.ButtheunderlyingpathophysiologyofALIisnotcompletelyunderstood.TheHerpesVirusEntryMediator(HVEM),amemberofthetumornecrosisfactorreceptorfamily,hasbeenreportedtobeeitherpro-inflammatoryoranti-inflammatorydependingonthesituation/environmentand/ornatureofliganditengages.