【摘 要】
：
Tremorgenic neuromycotoxicosis caused by extrolites from several Penicillium species (e.g.Penicillium crustosum) is an important syndrome in domestic animal
【机 构】
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National Veterinary Institute Norway
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
Tremorgenic neuromycotoxicosis caused by extrolites from several Penicillium species (e.g.Penicillium crustosum) is an important syndrome in domestic animals.The potential hazard to humans remains unclear,although there have been a few documented cases.We have lately reported the accidental intoxication of six dogs suspected poisoned by the tremorgenic mycotoxin penitrem A,a secondary metabolite produced by Penicillium crustosum.Either Penicillium crustosum or penitrem A were detected in samples from all the cases studied.To our.knowledge,this is the first time the presence ofpenitrem A has been reported in organs from poisoned animals,especially in brain and liver.Following these findings and based on the onset of the cases reported we have conducted a study to determine the metabolic biotransformation of the neurotoxin as well as the possible involvement of the GABA-ergic and the glutamatergic systems in the central nervous system (CNS).The metabolism of penitrem A has been evaluated in vivo by p.o.administration to mice and in vitro after incubation with rat hepatocytes and microsomes.
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