Design,synthesis and biological evaluation of novel Fluoroquinolone derivatives as potential,selecti

来源 :第八届国际分子模拟与信息技术应用学术会议 | 被引量 : 0次 | 上传用户:fljk888
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Phosphoinosilide 3-kinase(PI3K) is an attractive target to potentially treat a range of disease stales as illustrated by more than 15 inhibitors now in clinical trials.We disclose herein the discovery of a new class of fluoroquinolone derivatives having improved potency toward PI3K.
其他文献
BLyS antagonists have become the therapeutic reagents in the treatment of autoimmune disorders.BLyS binding peptides and their Fc fusion proteins may be altemative BLyS antagonists in Such application
A series of 4-alkoxyquinazoline derivatives containing 1,3,4-oxadiaxole scafifold have been designed and synthesized,and their inhibitory activities were also tested against A549,MCF-7 and Hela.Of the
Predicting target-ligand interactions is a critical task of chemogenomics and plays a key role in virtual drug discovery.Moreover,it is important to lake insights into the molecular recognition mechan
Macrocyclic polyketides,biosynthesized by modular polyketide synthases(PKSs),have been developed successfully into generation-by-generation pharmaceuticals for numerous therapeutic areas.A great effor
The 2014-2015 Ebola virus(EBOV)outbreak in West Africa highlighted the urgent need for specific therapeutic interventions for infected patients.The human-mouse chimeric monoclonal antibody(mAb)cocktai
会议
LARP7.a member of the La-related proteins(LARPs),shares a conserved La module comprising the La-motif(LAM)and the RNA-recognition motif(RRM1),binding exclusively to the non-coding RNA 7SK.LARP7 is a c
会议
Liver X receptor α(LXRα)plays an important role in the cholesterol metabolism process,and LXRα activation can reduce atherosclerosis.In the present study,using an LXRα-GAL4 luciferase reporter screeni
Objectives: Drug-resistant Mycobacterium tuberculosis poses a great threat to human health.Tyrosyl-tRNA synthetase(TyrRS)is one of the aminoacyl tRNA synthetases that catalyse the attachment of amino
Organophosphorus agents(OPs)like sarin,VX,or soman could inhibit acetylcholinesterase activity and cause poisoning.OPs could bind many proteins,such as butyrylcholinesterase and albumin,and the adduct
There is a constant demand to develop new,effective,and affordable anti-cancer drugs.The traditional Chinese medicine(TCM)is a valuable and alternative resource for identifying novel anti-cancer agent
会议