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Intermedin (IMD) is a novel peptide related to calcitonin gene-related peptide (CGRP) and adrenomedullin (ADM), which may have localised actions as a modulator of cardiac function.The aim of the study is to explore the effect of IMD on angiotensin Ⅱ (Ang Ⅱ) and endothelin-1(ET-1) induced hypertrophy in ventricular myocyte of neonatal rat, and try to elucidate the possible mechanism.