【摘 要】
：
Emerging evidence has suggested the critical role of endothelial to mesenchymal transition (EndMT) in fibrotic diseases.The present study was designed to examine whether EndMT is involved in arsenic t
【机 构】
：
Department of Pharmacology (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of Chin
【出 处】
：
2016第十一届心血管药理专业委员会全国心脑血管药理学术会议
论文部分内容阅读
Emerging evidence has suggested the critical role of endothelial to mesenchymal transition (EndMT) in fibrotic diseases.The present study was designed to examine whether EndMT is involved in arsenic trioxide (As2O3)-induced cardiac fibrosis and to explore the underlying mechanisms.
其他文献
目的:随着人们生活方式以及饮食结构的不断变化,目前,高脂血症已经成为心脑血管病变潜在的高危因素.内皮细胞是血管壁组织和血液之间的第一道通透性屏障.大量的研究证明,高脂血症导致的血管内皮细胞损伤是其病理过程中的重要环节.本课题探索了内皮细胞上表达的G蛋白偶联受体124 (GPR124)在高脂血症的发生和发展过程中的作用,旨在为高脂血症的发病机制研究提供新的发现和证据.
Endothelium cell permeability is an important pathogenic progression of early-stage coronary arteriosclerosis.Accumulating evidence has demonstrated that the inflammasome plays a critical role in the
Introduction: It is well known that inflammatory response and immune activation play the important role in the occurrence and development of chronic heart failure (CHF).CD4+ CD25+ regulatory T (Treg)
Backbround: Although the differentiation of mammalian cardiomyocytes is extremely active during embryonic period, it will stop proliferation and withdraw from the cell cycle soon after birth.Cardiomyo
内皮功能障碍在高血压,糖尿病,动脉硬化等心血管疾病中发挥了重要作用,以往研究发现ClC-3氯通道蛋白能够通过影响平滑肌细胞的增殖与凋亡参与高血压诱导的脑血管重构过程,但ClC-3在高血压内皮功能调控中的作用还不明确.本研究将探讨ClC-3对血管紧张素Ⅱ诱导的高血压内皮功能不全的作用及其机制.研究发现,Angiotensin Ⅱ诱导的野生型高血压小鼠胸主动脉内皮依赖性舒张受到损伤,敲除ClC-3改善
On-site mortality in crush syndrome remains high due to lack of effective drugs based on definite diagnosis.Anisodamine (Ani) is widely used in China for treatment of shock,andactivation of α7 nicotin
Objectives: To investigate the inhibitory effect of ginsenoside Re on intimal hyperplasia induced by balloon-injury and to explore the role of NF-rd p65 signaling pathway in the process.METHODS: SD ra
背景和目的:糖尿病易致骨骼肌损害,其发生机制不清楚.研究表明,内源性一氧化氮合酶(NOS)抑制物非对称性二甲基精氨酸(ADMA)与胰岛素抵抗和糖尿病密切相关;我室最近研究发现,糖尿病大鼠血清ADMA浓度升高与其肝脏和心肌线粒体功能障碍有关;但糖尿病时升高的ADMA是否参与骨骼肌收缩功能损害及线粒体功能障碍尚未见文献报道.
BisphenolA (BPA) is a widely studied typical endocrine-disrupting chemical.The present study aimed to verify whetherBPA could induce proliferation of cardiac fibroblasts and collagen production leadin
Type 2 Diabetes Mellitus (T2DM) is characterized by insulin resistance (IR), but the underlying molecular mechanisms are incompletely understood.MicroRNAs (miRNAs) have been demonstrated to participat