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Olfaction plays an important role on emotion in our daily life.Pleasant odors are known to evoke positive emotions, induce relaxation and calmness.The protective effects of vanillin on depressive model rats were investigated by using a combination of behavioral assessments and neurotransmitter measurements.Before and after chronic stress experiment,and at the end of drug administration, body weight,immobility time of the forced swimming test, sucrose consumption and stress hormone levels were measured.