论文部分内容阅读
A large body of evidence has established MDM2 as a crucial negative regulator of p53 and the major suppressor of p53 function in tumors with wild-type (wt) p53.Therefore, by inhibiting MDM2 one might reactivate p53 in tumor cells, leading to their demise.Previous studies revealed that ribosomal proteins L23 (RPL23) inhibited MDM2-mediated p53 ubiquitination through direct binding to MDM2, and subsequently induced p53 level as well as its activity, suggesting that it might be a candidate for use in tumor gene therapy.