SPLUNC1 Regulates Cell Progression and Apoptosis through the Mir-141-PTEN/P27 Pathway, But is Hinder

• 作 者: ChenPan[1]PengShuping[1]LiXiaoling[1]ColvinWanshuraLE[2]XiongWei[1]JamesB.McCarthy[2]LiGuiyuan[1]GuoXiaofang[1]ZhouHoude[3]ZhangWenling[1]LiXiayu[1]YangJianbo[2]ZengZhaoyang[1]MaJian[1]ZhouMing[1]
• 机 构: Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, the Th
• 出 处: 肿瘤药学基础研究与临床应用国际论坛
• 发表日期: 2013年期

　　Little is known about the role of the host defensive protein short palate, lung and nasal epithelium clone 1 (SPLUNC1) in the carcinogenesis of nasopharyngeal carcinoma (NPC).Here we report that SPLUNC1 plays a role at a very early stage of NPC carcinogenesis.SPLUNC 1 regulates NPC cell proliferation, differentiation and apoptosis through miR-141, which in turn regulates PTEN and p27 expression.This signaling axis is negatively regulated by the EBV-coded gene LMP1.Therefore we propose that SPLUNC 1 suppresses NPC tumor formation and its inhibition by LMP1 provides a route for NPC tumorigenesis.