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Objective:To compare the efficacy and side effects of induction chemotherapy with docetaxel plus cisplatin and 5-Fu(TPF) or docetaxel plus cisplatin(TP) or gemcitabine plus cisplatin(GP) combined with concurrent chemoradiotherapy in treating locally advanced nasopharyngeal carcinoma(NPC).Methods:From January 2010 to August 2013,240 patients with locally advanced nasopharyngeal carcinoma treated in our department were randomized into TPF group (80 patients) or TP group (80 patients) or GP group (80 patients).