论文部分内容阅读
In multi-cellular organisms,expression regulation is one of the central mechanisms modeling lineage differentiation and cell-fate determination.Although much of our current knowledge on how transcription modulating lineage specification was built through the extensive surveys of TF binding sites,epigenetic modifications and gene expressions in a linear manner,it is well recognized that their communication is not linear but rather congregating within the large discrete foci termed "transcription factories" in three-dimensional nuclear space.In this talk,we will discuss the approaches used to construct spatial genomic organization and examine the influence of chromatin structure on lineage specific transcription.The current knowledge of chromatin conformation sets the stage for the full-scale dissection of spatial and temporal genome structures and their roles in orchestrating development.