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Objective: Chemokine (C-C motif) ligand 5 (CCL5) has been shown to play an important role in antimyco-bacterial immune responses.Previous studies have extensively reported that the CCL5-28C>G gene polymorphism is associated with susceptibility to tuberculosis (TB).However,the results of these studies have been inconsis-tent.To investigate the relationship between the CCL5-28C>G and the risk of TB,we performed a meta-analysis.Methods: We searched articles published before June 6,2014 from PubMed,CNKI,and Wanfang databases.Data were extracted from all eligible publications independently by two investigators and statistically analyzed.Odds ra-tios (OR) with 95% confidence intervals (Cl) were calculated to assess the strength of the association between CCL5 polymorphism and TB.Results: Four case-control studies including 647 TB cases and 726 controls were involved in the meta-analysis.Our meta-analysis indicated the CCL5-28C>G gene polymorphism was significantly associ-ated with increased risk of TB (G vs.C: 3.75,95% Cl =1.76-7.99;GG vs.CC: OR =30.26,95% Cl =14.28-64.12).Conclusion: Our results suggested that the-28C>G polymorphism is significantly associated with higher TB risk,which is opposite from previously published reports.However,the number of the study is limited,additional well-designed studies are required to elucidate the association between the CCL5-28C>G gene polymorphism and TB.