Hepatotoxicity induced by potassium dichromate in chickens

• 作 者: WANG Shengnan LIU Yanhan ZHANG Xiao XU Wang CHENG Ziqiang LIU Jianzhu
• 机 构: College of Veterinary Medicine, Research Center for Animal Disease Control Engineering Shandong Prov
• 出 处: 中国畜牧兽医学会兽医内科与临床诊疗学分会第八届代表大会暨学术研讨会
• 发表日期: 2015年4期
• 关键词: Cr (Ⅵ) hepatotoxicity blood biochemical antioxidant indicators

　　This study is to evaluate hepatotoxicity induced by potassium dichromate in chickens via drinking water.Seventy-two Hyland Brown chickens were randomly divided into 4 groups (24 chickens each group): Control group, Low-dose (2% LD50) Cr (Ⅵ) group, Middle-dose (6% LD50) Cr (Ⅵ) group, High-dose (10% LD50) Cr (Ⅵ) group.Potassium dichromate was given orally via drinking water to the chickens for 42 days mg/kg body mass daily respectively;the Control group was treated with the same volume of distilled water.Blood biochemical indexes (ALT, AST, GGT), antioxidant indicators (SOD, GSH, MDA) in liver homogenates and pathologic changes in tissues were detected at 14, 28 and 42 d respectively.The levels of serum biochemical indexes (ALT, AST, GGT) were all increased significantly (P<0.05) in Cr (Ⅵ)-treated groups.The activities of SOD and GSH were decreased significantly (P<0.05) in the Cr (Ⅵ)-treated groups while the content of MDA increased significantly (P<0.05) in the Cr (Ⅵ)-treated groups with the increasing dose and extending time.The cells of the liver treated with Cr (Ⅵ) were severely dilated and congested space, and the liver appeared severe inflammation and necrotic hepatocyte.The results indicated that Cr (Ⅵ) can lead to hepatotoxicity damage in chicken with time-and dose-dependent relationship.