【摘 要】
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The aim is to investigate the effects of Zhuang Jin Xu Gu (ZJXG) decoction on the serum levels of growth hormone (GH), calcitonin (CT) and parathyroid hormone (PTH) and the femoral fracture healing in
【机 构】
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Institute of Integrative Medicine, Affiliated Hospital of Qingdao University Medical College, Qingda
【出 处】
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第二届中国针灸学会针灸康复专业委员会第二次学术会议、第三届山东中西医结合学会康复医学专业委员会第一次学术会议、第一届山东
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The aim is to investigate the effects of Zhuang Jin Xu Gu (ZJXG) decoction on the serum levels of growth hormone (GH), calcitonin (CT) and parathyroid hormone (PTH) and the femoral fracture healing in rats.Femur fractures were generated in 72 male adult Wistar rats by cutting femur transversely at middle point.ZJXG decoction was administered orally after surgery for 28 d.The healing process was analyzed by X-ray, gross anatomy and hematoxtlin-eosin (HE) staining.The serum levels of GH, CT and PTH were assessed by enzyme linked immunobsorbent assay (ELISA).X-ray, gross anatomy and HE staining indicated that the fracture line of the femoral fracture-end was clear at 7d, fibrous callus tissue formed at 14d,Calcium salt deposited at 21d and osseous callus tissues formed at 28d.During fracture 7-21d, no difference of the callus tissues structure existed between model and treatment groups, but in treatment group it was better than that in model group at 28d.ELISA results showed that the serum levels of GH, CT and PTH were higher than those in control group at 7-28 d (P<0.05).There were no significant difference between model and treatment groups at 7-21d, but in treatment group it was higher than that in model group at 28d (P<0.05).It is concluded that ZJXG decoction could promote the fracture healing by reducing the decomposition of GH, CT and PTH and keeping their high levels in femur fracture rats.
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