Amyotrophic lateral sclerosis (ALS), partly caused by the mutations and aggregation of human copper, zinc superoxide dismutase (SOD 1), is a fatal degenerat
Amyloidosis occurs in a crowded and confined environment in vivo, which contains polysaccharides, proteins, and nucleic acid.Some previous reports have show
Most lipases contain a lid domain to shield the hydrophobic binding site from the water environment.The lid, mostly in helical form, can undergo a conformat
Cystatins are important natural cysteine protease inhibitors (CPIs).The cysteine proteases include C1 family (papain-like) and C 13 family (legumains).The C