HDAC5 cytoplasma translocation is involved in angiotensin Ⅱ induced cardiac fibroblast proliferation

• 作 者: YunjianBao;WeiZhang;WeizhongZhu;
• 机 构: Department of Pharmacology, School of Medicine, Nantong University, Nantong, China
• 出 处: 江苏省药理学会第六届学术研讨会
• 发表日期: 2012年期

　　Aim:To observe whether cytoplasmic translocation of histone deacetylase 5 (HDAC5) is involved in cardiac fibroblast (CF) proliferation induced by Angiotensin Ⅱ (Ang Ⅱ) in cultured neonatal rat cardiac fibroblasts (CFs).Methods:CF was seperated from neonatal SD rats.Angiotensin type 1 receptor (AT1) agonist Angiotensin Ⅱ (Ang Ⅱ) was used as an irritant agent.CF proliferation was assessed by a cell survival assay (MTT) and cell counts.