【摘 要】
：
RNA interference(RNAi) technology has developed rapidly as a powerful tool for functional genomic analysis and target validation.Due to its potential for hi
【机 构】
：
AM Biotechnologies,USA
【出 处】
：
第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
RNA interference(RNAi) technology has developed rapidly as a powerful tool for functional genomic analysis and target validation.Due to its potential for highly specific targeted effects in vivo,there is significant interest in using RNAi as therapeutic agents in metabolic diseases,cancer,AIDS,malaria,neurodegenerative disorders,dental diseases and other illnesses.Unmodified siRNA is able to satisfy most laboratory research needs;however,therapeutic applications of unmodified siRNA in vivo are much less effective mainly due to the its rapid degradation in blood and elimination by excretion.Given these observations,developing methods for improving siRNA biochemical and biophysical properties in vivo is important for exploiting siRNA based therapeutic applications.
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