【摘 要】
：
LKB1 loss-of-function mutations,observed in approximate 30％ of human lung adenocarcinomas,contribute significantly to lung cancer malignancy progression.We demonstrate that lysyl oxidase (LOX),negativ
【机 构】
：
Laboratory of Molecular Cell Biology,Institute of Biochemistry and Cell Biology,Shanghai Institutes
【出 处】
：
中国科学院“百人学者论坛”2010年学术年会
论文部分内容阅读
LKB1 loss-of-function mutations,observed in approximate 30％ of human lung adenocarcinomas,contribute significantly to lung cancer malignancy progression.We demonstrate that lysyl oxidase (LOX),negatively regulated by LKB1 through mTOR-HIF-1α signaling axis,mediates lung cancer progression.Inhibition of LOX activity dramatically alleviates lung cancer malignancy progression.Up-regulated LOX expression triggers excess collagen deposition in Lkb1 deficient lung tumors,and thereafter results in enhanced cancer cell proliferation and invasiveness through activation of β1 integrin signaling.High LOX level and activity correlate with poor prognosis and metastasis.
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