【摘 要】
：
目的：阻塞性睡眠呼吸暂停综合征(OSAS)一种发病率较高的睡眠呼吸疾患，其心血管合并症对人体造成严重危害。合并症发生主要的原因是慢性间歇低氧(CIH)导致的血管内皮功能障碍。目前OSAS 诱发心肌损伤相关的lncRNAs 分子调控机制并不清楚。因此，我们建立CIH 大鼠模型，分析其左心室lncRNAs 芯片表达谱并探讨其相关潜在功能，进一步明确OSAS 诱发心肌损伤相关lncRNAs 的分子机制，
【机 构】
：
福建医科大学附属第一医院呼吸与危重医学科,福建省福州市茶中路20 号,350005
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目的：阻塞性睡眠呼吸暂停综合征(OSAS)一种发病率较高的睡眠呼吸疾患，其心血管合并症对人体造成严重危害。合并症发生主要的原因是慢性间歇低氧(CIH)导致的血管内皮功能障碍。目前OSAS 诱发心肌损伤相关的lncRNAs 分子调控机制并不清楚。因此，我们建立CIH 大鼠模型，分析其左心室lncRNAs 芯片表达谱并探讨其相关潜在功能，进一步明确OSAS 诱发心肌损伤相关lncRNAs 的分子机制，对于防治OSAS 相关心肌损伤，改善患者生命质量具有重要意义。
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