【摘 要】
：
Developmental disorder of functional neural circuits at early stage in central nervous system(CNS)contributes to deficits in autism spectrum disorders(ASD).Endogenous electrical activity and activity
【机 构】
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Shanghai Institute of Materia Medica,Chinese Academy of Sciences,China
【出 处】
：
2015年中国生物医学工程联合学术年会
论文部分内容阅读
Developmental disorder of functional neural circuits at early stage in central nervous system(CNS)contributes to deficits in autism spectrum disorders(ASD).Endogenous electrical activity and activity dependent plasticity are vital for growth of neurons,appropriate modification of synapses,and correct connection of functional neural circuits.Abnormal firing pattern or aberrant integration of firing pattern of endogenous electrical activity resulted in serious functional disorders in CNS.Functional neural circuits have critical period at early development stage,respectively.Until now,when and how the abnormality of neural microcircuits of amygdala at early development stage in ASD are still unclear.Here,we study dynamic characteristics of endogenous electrical activity and short term plasticity of neural microcircuits of postnatal amygdala in ASD model mice.By combining patterning electric stimulation with extracellular recording in microelectrode array(MEA),we found that the abnormality of firing pattern of endogenous electrical activity and short term plasticity of neural microcircuits of postnatal amygdala in the critical period,P11-P12 development stage,in ASD model mice.These results suggest that in the critical period,P11-P12 stage,firing pattern of endogenous electrical activity and short term plasticity of neural microcircuits of postnatal amygdala are abnormal in ASD.
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