论文部分内容阅读
Pirt is a transmembrane protein predominantly expressed in peripheral neurons.However,the physiological and pathological roles of Pirt in hollow viscus are largely unknown.Here we show that Pirt deficiency in mice causes bladder overactivity.The density of α,β-meATP-induced currents is significantly reinforced in Pirt-deficient dorsal root ganglion(DRG)neurons.