Hydrogen Peroxide Primes Heart Regeneration with a Derepression Mechanism

来源 :第三届全国斑马鱼研究大会 | 被引量 : 0次 | 上传用户：huangyqing

【摘要】

：

　　While the adult human heart has very limited regenerative potential,the adult zebrafish heart can fully regenerate after 20% ventricular resection.Although

【作者】

：

Peidong Han Jupeng Diao Yi-Song Zhen Xiaojun Zhu Chuan-Yun Li Heping Cheng Jingwei Xiong Xiaohai Zhou Nannan Chang Chenglu Xiao Shouyu Yan Xinzhuang Yang Meiling Zhang Qing Wu Boyang Tang

【机构】

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InstituteofMolecularMedicine,thePeking-TsinghuaCenterforLifeSciencesInstituteofMolecularMedicine,the

【出处】

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第三届全国斑马鱼研究大会

【发表日期】

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2013年10期

【关键词】

：

zebrafish heart regeneration H2O2 Duox Erk1/2 Dusp6 derepression

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　　While the adult human heart has very limited regenerative potential,the adult zebrafish heart can fully regenerate after 20% ventricular resection.Although previous reports suggest that developmental signaling pathways such as FGF,PDGF and RA are reused in adult heart regeneration,the underlying intracellular mechanisms remain unknown.Here we show that H2O2 acts as a novel epicardial and myocardial signal to prime the heart for regeneration in adult zebrafish.Live imaging of intact hearts revealed highly localized,Duox-generated H2O2(~30 μM)in the epicardium and adjacent compact myocardium at the resection site.

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Hydrogen Peroxide Primes Heart Regeneration with a Derepression Mechanism

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