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Design exploration at the system level is still much of an art: design methodologies exist that help the system architect to transform high-level models to a system description that can be implemented on a SoC or embedded system. The EDA market however is still reluctant to support these methodologies in their tool chain, very often because most solutions are specific for a certain application family. System architects tend to use their own (undocumented) box-of-tricks to achieve the desired results. At IMEC we have a research tradition on application specific system design methodologies, in order to better understand and control the process of system refinement to an efficient and feasible implementation. In this paper an overview will be given of the results that have been obtained up to now, and the roadmap will be given of the challenges that lay ahead.