论文部分内容阅读
目的探讨阻塞性睡眠呼吸暂停综合征(OSAS)患者的脑血流动力学变化。方法40例符合OSAS诊断标准的患者入选试验组,40例健康人作对照组。对上述受检者进行经颅多普勒超声(TCD)检查:观察颅内动脉血流速度,有无狭窄、闭塞、血流频谱改变。结果40例OSAS患者中,TCD检查异常33例(33/40,82.5%),其中血流速度减慢27例(67.5%),血管狭窄(17.5%)6例;40例对照组中,TCD检查发现异常7例(17.5%),OSAS患者TCD异常检出率显著高于对照组(χ2=48.5,P<0.01)。随访1年,OSAS患者6例有脑血管事件发生(15.0%),对照组中仅1例脑血管事件发生(2.5%),两者比较差异具有统计学意义(P<0.05)。结论OSAS患者由于长期缺氧易发生动脉硬化,导致脑血流减低和/或脑动脉狭窄。OSAS程度越严重,脑血流动力学异常的发生率也越高,脑血管事件发生的危险性也越大。
Objective To investigate the changes of cerebral hemodynamics in patients with obstructive sleep apnea syndrome (OSAS). Methods Forty patients with OSAS diagnostic criteria were enrolled in the experimental group and 40 healthy individuals as the control group. Transcranial Doppler ultrasonography (TCD) was performed on the above subjects: the intracranial arterial blood flow velocity was observed, with or without stenosis, occlusion, and changes of blood flow spectrum. Results Among the 40 patients with OSAS, TCD was abnormal in 33 cases (33/40, 82.5%), of which 27 cases (67.5%) and 6 cases of vascular stenosis (17.5%) were slowed down. TCD In 7 cases (17.5%) of abnormal findings, the detection rate of TCD abnormalities in OSAS patients was significantly higher than that in controls (χ2 = 48.5, P <0.01). One year follow-up showed that six patients with OSAS had cerebrovascular events (15.0%) and only one cerebrovascular event (2.5%) in controls. The difference was statistically significant (P <0.05). Conclusion Patients with OSAS are prone to develop atherosclerosis due to prolonged hypoxia, resulting in decreased cerebral blood flow and / or stenosis of cerebral arteries. The more severe the degree of OSAS, the higher the incidence of cerebral hemodynamic abnormalities, the greater the risk of cerebrovascular events.