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Objective:The relationship between cervical lymphatic metastasis and TgAb is still not clear.This study is to investigate the relationship between positive TgAb and metastasis to cervical lymph nodes in Chinese population. Methods:A retrospective analysis was conducted on 595 consecutive patients who underwent thyroidectomy In Fujian Provincial Hospital between January and November in 2009.Ultrasonographic parameters,Serum concentrations of thyroglobulin antibodies (TgAb),s-TSH and other molecular markers were measu red before thyroidectomy.Su rgical report confirmed the final outcome deciding a benign or malignant status. Results:There were 399 patients with benign thyroid nodules and 196 patients with malign thyroid nodules.Patients with malign nodules were likely to have smaller nodules (1.2+0.9 vs.1.6+1.0 cm; p<0.001),higher levels of s-TSH ( 2.3+3.2 vs.1.6+2.2 mIU/I; p=0.008),lower HDL-C levels( 1.3+0.3 vs.1.4+0.4 mmol/L; p=0.017),higher positive rate and levels of TgAb (5.9% yS.20.6%,6.8+12.2 vs.16.0+22.1 mIU/L; both p<0.001).In the multivariate analysis,malignant nodule was associated with TgAb (OR=1.035,95%C1:1.018--1.052),HDL-C (OR=0.323,95%CI:0.147--0.707),lower sTSH level ( OR=0.328,95%CI:0.118-0.916),age,nodule size and nodule calcification.The prevalence of malignant cervical lymph nodules (MCLN) in the TgAb positive group was higher than the normal group (55.9 % vs.44.2%,p for the trend=0.224). Conclusion:Positive TgAb was associated with the thyroid cancer and a trend was demonstrated for the association with cervical lymph nodule metastasis in patients with thyroid cancer.There was a significant inverse association between HDL-C and the risk of thyroid cancer that is independent of LDL-C,TSH,age,sex.