【摘 要】
：
Although the nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cGMP dependent protein kinase (PKG) pathway in hippocampus has been shown to be important for long term learning and memory, little is kno
【机 构】
：
Neuroscience Research Institute, Peking University; Department of Neurobiology, School of Basic Medi
【出 处】
：
中国神经科学学会第九届全国学术会议暨第五届会员代表大会
论文部分内容阅读
Although the nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cGMP dependent protein kinase (PKG) pathway in hippocampus has been shown to be important for long term learning and memory, little is known about its role in drug-induced reward memory.In the present study, we firstly investigated the possible involvement of PKG in the acquisition, expression and consolidation of conditioned place preference (CPP) induced by morphine in male SD rats.Results showed that Rp-8-Br-PET-cGMPs, a PKG inhibitor, selectively impaired the consolidation of morphine CPP when it was microinjection into CA1 region of the hippoeampus immediately after each conditioning session.However, Rp-8-Br-PET-cGMPs had no effect on the acquisition or expression of morphine CPP when it was microinjection into the CA1 region before each conditioning session or before the test of morphine CPP.Furthermore, pharmacological intervention of NO and sGC in the CA1 region using NO synthase (NOS) inhibitor (7-NI) and sGC inhibitor (ODQ) also significantly blocked the consolidation of morphine CPP.The present study for the first time show that the NO/sGC/PKG signaling pathway in the hippocampal CA1 region may play a critical role in the consolidation of morphine induced reward memory.
其他文献
Objective The 14-3-3 family, a group ofmultifunctional acidic proteins, exists predominantly in the brain.Up-regulation of 14-3-3γ is neuro-protective and crucial in protecting astrocytes from ischemi
Objective Netrin-1 is one of the axon-guiding molecules that are critieal for neuronal development.Netrin-1 was found to stimulate the proliferation and migration of human cerebral endothelial cells i
Objective Mutations in the PLA2G6 gene at the PARK14 locus have been reported in complicated parkinsonism patients.To assess the prevalence of and phenotypes associated with PLA2G6 gene mutations, we
Objective Elevated iron accumulation has been reported in the substantia nigra (SN) in Parkinsons disease (PD).Our previous study observed that increased levels of the iron importer divalent metal tra
Objective There is increasing interest in interactions between the nigrostriatal dopamine (NSD) system and the circadian system in Parkinsons disease.The two systems are mainly involved in neurotransm
Objective Neurodegenerative diseases accompany neuroinflammatory pathological process, during which injury or loss of neurons often occurs.As a result, cognition, learning or movement function is seve
ApoE4, with an allele frequency of 14% in these populations, is linked to an increased risk of developing sporadic AD as well as a decreased age of onset compared to inherited apoE3.Recent studies sug
Objective Early exposure to enriched environment may deeply influence the developing synaptic plasticity and this effect can transmit to offspring.Prolonged febrile seizures (FSs) are associated with
目的 低氧是常见的病理生理状态,铁代谢紊乱是脑卒中等低氧损伤的重要病理过程.近年来研究发现越来越多的与铁代谢相关的蛋白,并陆续发现多种铁代谢相关蛋白通过低氧反应元件(hypoxia-response element,HRE),受到低氧诱导因子(hypoxia inducible factor, HIF)的直接调节.本研究目的是基于基因表达数据整合和现有HRE序列特征,寻找新的受HIF直接调节的铁代
Neural stem cell transplantation is a major focus of current research in treatment of spinal cord injury (SCI).However, it is very important to promote the transplanted neural stem cells (NSCs) differ