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Background: PRP can encourage hair growth by promoting cell survival.cell proliferation and encourage hair follicles into the anagen phase.Objective: This study was conducted to investigate the efficacy and safety of a combination of non-ablative fractional laser and platelet-rich plasma(PRP)for the treatment of male and female androgenetic alopecia(AGA).Methods: Fourteen women(Ludwig I-Ⅱ.mean aged 43.1(25-63))and nine men(NW Ⅱ-Ⅳ mean aged 41.3(32-55)completed the study.Three sessions of fractional l.927 nm Thulium doped fiber laser(Lasemd,Lutronic Inc,South Korea)followed by PRP injection on the affected area at 1-month interval.Non-activated PRP was prepared using Ycellbio-kit(Ycellbio Medical Co.,Ltd.,South Korea).Hair growth was evaluated using(i)standardized global photographs,(ii)hair mass(Haircheck),(iii)target area hair counts(Trichoscale,Fotofinder),and(iv)self-assessment questionnaires at baseline,3 and 6 months after the last treatment.Results: At 6 months after complete three treatments,global photography showed improvement in all patients(7 slight,6 moderated,and 10 marked improvement)compared to baseline.The terminal hair counts significant increased from baseline by 23.8%(85.52 to 105.87 = 20.35 hairs,p=0.000).The percent increase of total hair count was 9.88%(132.43 to 145.52 = 13.09 hairs,p=0.004).Hair mass index which increased from baseline by 10.1%(27.7 to 30.5,p=0.004).The treatment was fair-tolerated and the mean VAS for pain was 1.09(0-4)and 4.23(1-8)for laser treatment and PRP injection,respectively.Adverse effects were limited to transient erythema and mild burning sensation on treated area.Broken hair shaft was not found in our patients.Conclusion: A combination of a 1,927 nm fractional Thulium doped fiber laser and PRP is a safe and effective adjunctive treatment for both male and female AGA.However,larger and longer,randomized,placebo-controlled trials are suggested.