血浆miRNA作为肝癌早期诊断生物标志物的流行病学研究

来源 :2015中国转化医学大会暨中国转化医学联盟成立大会 | 被引量 : 0次 | 上传用户：yhl0921

【摘要】

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目的：探讨肝癌组织来源的血浆miRNA在肝细胞肝癌(HCC)患者中的表达并评估血浆miRNAs作为HCC早期诊断标志物的价值.方法：采用三阶段研究设计.第一阶段，在HCC患者肝癌移植术或肝癌切除术前及术后的血浆样本和肝癌患者的癌组织、癌旁组织及肝硬化患者的肝硬化组织中通过TLDA芯片系统筛选差异表达的miRNA.第二阶段，采用病例对照研究设计在大样本HBV阳性HCC患者和HBV携带者中验证第一阶段

【作者】

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闻洋韩静陈建国董静夏永祥刘继斌江珢戴俊程靳光付孙倍成胡志斌沈洪兵

【机构】

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南京医科大学公共卫生学院流行病与卫生统计学系启东肝癌防治研究所;南通大学附属肿瘤医院

【出处】

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2015中国转化医学大会暨中国转化医学联盟成立大会

【发表日期】

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2015年3期

【关键词】

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肝细胞肝癌 miRNA 血浆早期诊断生物标志物

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血浆miRNA作为肝癌早期诊断生物标志物的流行病学研究

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