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目的探讨急性心肌梗死(acute myocardial infarction,AMI)患者发病时的心脏标志物与6个月后健康相关生存质量的关系。方法测定106例2004-12~2006-11期间急诊AMI患者发病时N-端脑利钠肽前体(NT-proBNP)、肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)和乳酸脱氢酶同工酶1(LD1)。6个月后应用SF-36量表对患者的生存质量进行调查,通过多元线性回归分析法筛选出与生存质量有关的标志物。结果SF-36量表总评分和躯体功能、一般健康状况、情感角色等维度评分与NT-proBNP有负线性关系(P均<0.05)。总评分和躯体角色、肌体疼痛等维度评分与cTnI有负线性关系(P均<0.05)。躯体功能维度评分与CK-MB有负线性关系(P<0.05)。结论AMI患者发病时NT-proBNP、cTnI和CK-MB浓度较高,与发病后6个月的生存质量较低有关,三种标志物对生存质量均具有一定的预示作用。
Objective To investigate the relationship between cardiac markers and the health-related quality of life after 6 months of onset of acute myocardial infarction (AMI). Methods The levels of NT-proBNP, cTnI and CK-MB in 106 patients with acute AMI during the period from December 2004 to December 2006 were measured. ) And lactate dehydrogenase isoenzyme 1 (LD1). Six months later, the quality of life of the patients was investigated using the SF-36 scale and the quality of life-related markers were screened by multivariate linear regression analysis. Results There was a negative linear relationship between the total score of SF-36 scale and NT-proBNP (all P <0.05) with the scores of physical function, general health status and emotional role. There was a negative linear relationship between the scores of total score and somatosensory, body pain and cTnI (all P <0.05). Body function dimension score had a negative linear relationship with CK-MB (P <0.05). CONCLUSIONS: The levels of NT-proBNP, cTnI and CK-MB in patients with AMI are higher than those at 6 months after onset. The quality of life of the three markers has certain predictive value.