Metabolites of Polybrominated Diphenyl Ethers in Mouse Plasma after Exposure to a Commercial Pentabr

• 作 者: Xing-HuaQiu[1]MinervaMercado-Feliciano[2]RobertM.Bigsby[3]RonaldA.Hites[1]
• 机 构: School of Public and Environmental Affairs,Indiana University,Bloomington,USA
• 出 处: 第四届持久性有毒化学污染物国际研讨会(The 4th International Symposium on Persis
• 发表日期: 2007年期

　　Polybrominated diphenyl ethers (PBDEs) have become important environmental pollutants,and their in vivo metabolites are suspected of disturbing hormone function because the structures of PBDEs metabolites are similar to human hormones,such as thyroxine and estrogen.To study the metabolites of PBDEs,mice were continuously dosed orally and subcutaneously to DE-71,a widely used commercial pentabromodiphenyl ether product,for 34 days.