【摘 要】
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We examined the protective effect of L-citrulline on ethanol-induced gastric ulcer in rats.The gastric lesions were significantly attenuated by all doses of
【机 构】
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Department of Pharmacy, Xuzhou Medical College, Jiangsu, China
论文部分内容阅读
We examined the protective effect of L-citrulline on ethanol-induced gastric ulcer in rats.The gastric lesions were significantly attenuated by all doses of L-citrulline as compared to the ethanol (0.8ml/kg body weight) treatment group.Pretreatment with L-citrulline prevented the oxidative damage as well as the increase of the myeloperoxidase (MPO) activity.The gastric mucosal constitutive NO synthase (cNOS) and inducible NO synthase (iNOS) activities were also investigated in tissues of all groups.The administration of L-citrulline increased the eNOS activity and decreased the iNOS activity as compared to ethanol-treated group.Analysis of serum cytokines of ethanol-induced rats showed a moderate decrease in interleukin-10 (IL-10) with considerable increase of interleukin-6 (IL-6) while L-citrulline inhibited the acute alteration of cytokines.These results suggest the gastroprotective effect of L-citrulline.
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