Identification of Epigenetic Regulator MMSET as a Biomarker in the Pathogenesis of Lymphoma

来源 :The 35th World Congress of the International Society of Hema | 被引量 : 0次 | 上传用户：grandbill

【摘要】

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【作者】

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Mingyi Chen June Zou Hong-Wu Chen Ralph Green

【机构】

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Departments of Pathology and Laboratory Medicine,University of California at Davis Medical Center

【出处】

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The 35th World Congress of the International Society of Hema

【发表日期】

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2014年5期

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Purpose MMSET (WHSC1/NSD2) is a SET domain-containing histone H3K36 methyltransferase.Its expression is deregulated in a subgroup of multiple myelomas (MM) with the t(4;14)(p16;q32)translocation associated with poor prognosis.Our goal is to study the role of MMSET in switching global chromatin histone methylation and gene expression in diffuse large B-cell lymphoma (DLBCL).

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Identification of Epigenetic Regulator MMSET as a Biomarker in the Pathogenesis of Lymphoma

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