【摘 要】
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目的 探讨精神病未治疗时间(DUP)对首发精神分裂症患者认知功能及预后的影响.方法 选取68例未服药首发患者,应用精神分裂症首发症状评定量表(SOS)确定DUP,按照DUP中位值分为短DUP(n=33)组和长DUP组(n=35),分别于基线、治疗后3个月、12个月分别采用WCST、P300测定认知功能,并与35例正常对照比较.采用重复测定资料的方差分析,比较2组患者认知功能的差异.结果 ①治疗前,
【出 处】
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首届浙江省精神卫生专科联盟学术会议暨第四届精神病学与临床心理学国际高峰论坛
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目的 探讨精神病未治疗时间(DUP)对首发精神分裂症患者认知功能及预后的影响.方法 选取68例未服药首发患者,应用精神分裂症首发症状评定量表(SOS)确定DUP,按照DUP中位值分为短DUP(n=33)组和长DUP组(n=35),分别于基线、治疗后3个月、12个月分别采用WCST、P300测定认知功能,并与35例正常对照比较.采用重复测定资料的方差分析,比较2组患者认知功能的差异.结果 ①治疗前,2组患者认知功能与对照组差异均有统计学意义(P=0.000～0.006),与长DUP患者相比,短DUP患者除在分类完成数、P300潜伏期无差异外(P=0.393、0.484),其他认知功能评定的差异均有统计学意义(P：0.000-0.046)；②治疗后,长DUP组患者认知功能部分恢复,但仍有异于对照组,差异有统计学意义(P=0.000-0.026),短DUP组患者仅在分类完成数、P30o波幅与对照组的差异仍有统计学意义(P=0.042、0.000)；③治疗后,除分类完成数外,短DUP组患者认知功能恢复均优于长DUP组,差异有统计学意义(F=4 258～6.764,P=0.017～0.045).结论 DUP对首发精神分裂症患者认知功能预后有重要影响.预防长DUP的发生,将有助于认知功能的恢复.
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