IN VITRO AND IN VIVO EVALUATION OF WELL-DEFINED WATER SOLUBLE BLOCK COPOLYMERS AS ANTICANCER DRUG CA

来源 :The 6th International Symposium on Polymer Chemistry(2014年第六 | 被引量 : 0次 | 上传用户:mubila
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Well-defined water-soluble block copolymers poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide-co-N-methacryloylglycylglycine) (PEG-b-P(HPMA-co-MAGG)) with different composition,molecular weight and narrow polydispersity were synthesized by reversible addition-fragmentation transfer (RAFT) polymerization.After labeled with radionuclide 125I and FITC,the in vitro cell uptake of copolymer with different negative charge by murine hepatocytes (NCTC-1469) was investigated.
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