【摘 要】
：
Dioxins, also often referred by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), have been listed as persistent and most toxic organic pollutants.In this study,
【机 构】
：
Department of Chemistry, Hong Kong Baptist University, Kowloon, Hong Kong SAR, China
【出 处】
：
第2届大连国际色谱学术报告会、第37届国际高效液相色谱及相关技术会议、第18届全国色谱学术报告会
论文部分内容阅读
Dioxins, also often referred by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), have been listed as persistent and most toxic organic pollutants.In this study, liquid chromatography/quadrupole time-of-flight mass spectrometry was employed to investigate the toxic effect of TCDD in blood, liver and skeletal muscle tissues of C57BL/6J (C6) as well as DBA/2J (D2) mice.By using non-targeted metabolomic approach in conjunction with multivariate data analysis, hundreds of ions were aligned and extracted with P-value and fold-change in mice exposed to TCDD compared to control group.As a result, in aryl hydrocarbon receptor (AhR)-sensitive mouse model-C6, fatty acid beta-oxidation was markedly enhanced.Meanwhile, perturbation of other metabolic pathways was also observed, namely the accumulation of fatty acids and lysophospholipids, the reduced amino acid biosynthesis and the decreased purine metabolism.
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