目的:通过检测前列腺癌患者以及健康志愿者外周血中CD4+CD25high调节性T细胞、TGF-β1及COX-2的表达,初步探讨CD4+CD25 high调节性T细胞在前列腺癌发病机制中的作用及其与TGF-β1和COX-2的相关性.方法:应用流式细胞术检测30例前列腺癌患者治疗前后(其中前列腺癌局限组1 1例,非局限组19例)及20例健康志愿者外周血单个核细胞(PBMC)中CD4+ CD25high
OBJECTIVES:To investigate whether silencing of p21-activated kinase 6 (PAK6) would inhibit prostate cancer growth and to assess the effect of PAK6 silencing when used in combination with docetaxel.PAK
Human interacting protein X1 (PinX1) was recently identified as a putative tumor suppressor in several types of human cancer,due to its binding to and inhibition of telomerase.And loss of PinX 1 has b
目的:探讨Lin28/ let-7a /c-Myc通路及其相关分子在浅表性膀胱癌中的作用.方法:正常膀胱组织及浅表性膀胱癌标本分别以RT-PCR、Western blot及免疫组化方法,检测pre-let-7a、let-7a、Lin28、c-Myc RNA及Lin28、c-Myc蛋白的表达.结果:pre-let-7a的表达随膀胱癌分化程度的降低而升高,let-7a的表达变化则与pre-let-7a
Aim:Receptor for advanced glycation end products (RAGE),along with its ligand high mobility group box 1 (HMGB1),is believed to play an important role in prostate cancer.The aim of this retrospective s
目的:睾丸腺瘤样瘤是临床少见的良性肿瘤,本文报告1例原发性睾丸腺瘤样瘤患者的临床资料,并结合文献复习讨论,探讨原发性睾丸腺瘤样瘤的临床、病理、组织化学特性、诊治方法及预后.一般资料:患者,男,40岁.主诉"无意中发现左侧睾丸肿块2周",患者体检时触及左侧睾丸内肿物,直径1.0 cm×1.5cm左右,质地较硬、无压痛,边界清楚.实验室检查:血清甲胎蛋白(AFP)、人绒毛膜促性腺激素(B-HcG)均在
Objective:To study the expressions of the BRMS1 gene and its clinical significance in prostate cancer.Methods:80 samples of prostate cancer and 35 samples of benign prostate hyperplasias were collecte
目的:研究BRMS1基因在前列腺癌中的表达及临床意义.方法:收集我院2008年01月～2011年05月期间行前列腺癌根治术后的石蜡包埋标本80例,良性前列腺增生组织石蜡包埋标本35例.应用免疫组化超敏型二步法,检测前列腺癌和前列腺增生组织中BRMS1的表达情况,分析BRMS1的表达与临床病理参数之间的关系.结果:BRMS1蛋白在前列腺癌和前列腺增生组织中的阳性表达率分别为40.00％(32/80)
Objective:The aim of the current study was to investigate the association between body mass index (BMI) and oncological outcomes in Chinese patients who had undergone radical nephroureterectomy (RNU)
Background:A regulator of the protein phosphatase 2A,α4,is upregulated in several types of human cancer and possesses an oncogenic role.However,the abnormalities of α4 and its underlying mechanisms in