miR-146a-5p promoted cell proliferation of cervical cancer cells mainly by regulating NF-kappaB path

• 作 者: Hu Qiming Zhou Delan Liang Jiale Han Suping
• 机 构: Department of Obstetrics & Gynecology, the First Affiliated Hospital of Nanjing Medical University 2
• 出 处: 江苏省第十五次妇产科学学术会议
• 发表日期: 2015年11期
• 关键词: cervical cancer miR-146a cell proliferation TRAF6 IRAK1

　　Objective: Recent research indicates that microRNAs (miRNAs) are frequently dysregulated in human therioma,and many studies shown that miR-146a-5p is upregulated in cervical cancer.Modulation of nuclear factor NF-kappaB activation may play a key role in regulating inflammatory conditions associated with cervical cancer.In this study,we investigated the influence of the miR-146a GC rs2910164 on miR-146a expression,and the role of the miR-146a-5p on Cell proliferation and apoptosis in cervical cancer.