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More than half of the world population still heavily relies on traditional herbal medicines,mostly complex botanical combinations(e.g.,TCM),for their health care needs.Botanical derived natural products have been one of the most important sources for purified drugs,with artemisin and paclitaxel as two of the best known examples.Although many TCM herbs and formulated products for oral use can be marketed as dietary supplements,further development of TCM products into new botanical drugs could make greater differences in the areas that new,safe,and effective medicines are dearly needed.