【摘 要】
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Transition metal-catalyzed reactions for the direct functionalization of C-H bonds, especially sp3 C-H bonds for the construction of carbon-carbon and carbon-heteroatom bonds, has provided a great imp
【机 构】
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Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central
【出 处】
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中国化学会全国第十一届有机合成化学学术研讨会
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Transition metal-catalyzed reactions for the direct functionalization of C-H bonds, especially sp3 C-H bonds for the construction of carbon-carbon and carbon-heteroatom bonds, has provided a great impetus to modem organic synthesis.1 Iodine catalyzed C-H bond functionalization reactions, which are driven by radical-and in situ iodination-based pathways, have recently been used in the successful development of complementary methods for the direct activation of C-H bonds.2 Despite these recent advances, research towards the development of iodine catalyzed methods for the direct functionalization of C-H bonds is still in its infancy, and plenty of opportunities still exist to further explore this fascinating area.In contrast to ketones, esters,3 and oxindoles,4 reports pertaining to the direct functionalization of the α-Csp3-H bonds of simple amides remain scarce,5 most likely because of the high pKa values (pKa ＞ 35 in DMSO) of amide α-C-H bonds[6] and the potential for the formation of by-products.
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