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Electrospinning is an attractive technology for producing nanofibrous membrances in applications such as tissue engineering, energy, water filtration, biotechnology and sensors.For tissue regeneration and bioengineering applications, there is a growing interest in fabricating tailored 3D scaffolds with a complex tissue-like structure, i.e., nanometer diameter, aligned fibers and controllable thickness that may be suitable for specific organs and tissues.However, so far, conventional electrospinning setups were still plagued by some problems, such as produce 2D nanofibrous aligned membranes with limited thickness, or fabricate 3D scaffolds with random fibers and a micrometer fibrous diameter.In this work, a novel electrospinning setup which contained two devices, a parallel double thin plate collection device to collect aligned fibers and a unique fiber removal device to obtain expectable thick membrane were designed.Based on these two separated but connected devices, nanofibrous PVA scaffolds with 76% of the fibers having an alignment degree within (5 (and thicknesses from micrometers to millimeters were successfully generated.After crosslinking by using PA and GA vapors, the construction of the nanofibrous architecture was stable enough to maintain its morphology upon contact with a liquid, and had higher mechanical strength than other 3D scaffolds generated by previous methods.In summary, this work developed an electrospinning system to fabricate thickness-controllable 3D scaffolds with ordered structure, which may be a powerful tool to apply materials to produce designable 3D constructs for specific application.