论文部分内容阅读
目的:比较酸根、碱基(或金属元素)不同盐类药物的药动学特点和临床疗效及安全性,为临床合理使用改盐制剂提供参考。方法:查阅国内有关文献进行比较分析。结果:改盐制剂由于只改变了酸根、碱基(或金属元素)这些盐基,没有改变其起药理作用的活性分子结构或官能基团,所以一般没有改变其药理作用,仅改变了其理化性质,而理化性质的改变则常常引起药理作用程度的改变,临床疗效和(或)不良反应也不尽相同。结论:一些改盐制剂的临床疗效和(或)安全性存在差异或显著差异,临床使用时应权衡利弊。
OBJECTIVE: To compare the pharmacokinetic characteristics, clinical efficacy and safety of different salts of acid radical, base (or metal element), and provide a reference for the rational use of salt-changing agents in clinic. Methods: consult the domestic literature for comparative analysis. Results: The salt-changing agent did not change its pharmacological action and changed its physical and chemical properties only because it only changed the base of acid radical, base (or metal element), and did not change the active molecular structure or functional group which played a pharmacological role. Nature, and changes in physical and chemical properties are often caused by changes in the degree of pharmacological effects, clinical efficacy and (or) adverse reactions are not the same. Conclusions: There are differences or significant differences in the clinical efficacy and / or safety of some salt-changing preparations. The advantages and disadvantages should be weighed in clinical use.