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In nature, iron cations in magnetite are usually isomorphically substituted by divalent (Co, Ni, Zn, Cu, Mn, etc.), trivalent (Al, V, Cr, etc.) and tetravalent (Ti) cations while maintaining the spinel structure.Some of the substituting cations, e.g.Cr3+, V3+ and Mn2+, improve the catalytic activity of magnetite in heterogeneous Fenton reaction through the enhancement of hydroxyl radical ·OH production and the pollutant adsorption.