【摘 要】
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Direct C-H bond functionalization has attracted much attention due to high atom economy.Recently,reactions catalyzed by diselenide have been successfully applied in alkene functionalization such as am
【机 构】
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School of Chemistry and Chemical Engineering,Sun Yat-Sen University,Guangzhou,510275
【出 处】
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第五届岭南有机化学论坛暨华南理工大学-兰州大学有机化学双边论坛
论文部分内容阅读
Direct C-H bond functionalization has attracted much attention due to high atom economy.Recently,reactions catalyzed by diselenide have been successfully applied in alkene functionalization such as amination,cyclization,and dichlorination.N-Vinylpyridinium(NVP) salts are useful synthetic intermediates.Traditional methods to construct NVP salts from alkenes always proceed several steps or to use corrosive and toxic reagent bromine,which resulted in low yields and poor functional group compatibility.Recently,we developed a novel salts via organoselenium catalyzed direct C-H bond functionalization of alkenes under mild conditions using N-fluoropyridinium( NFP ) reagent.This is the first example of using NFP reagent as N-source in vinylic C-N bond formation.Mechanism study revealed that selenenylated pyridinium intermediate was formed during the catalytic cycle,indicating a selenenylation-deselenenylation process.
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