SULF2 methylation is associated with in vitro cisplatin sensitivity and clinical efficacy for gastri

来源 :2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议 | 被引量 : 0次 | 上传用户:suiye001
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objective Biomarkers capable of discriminating the patients who are likely to respond to certain chemotherapeutic agents could improve the clinical efficiency.The sulfatases (SULFs) play a critical role in the pathogenesis of a variety of human cancers.Here,we focused our investigation on the prognostic and predictive impact of SULF2 methylation in gastric cancer.
其他文献
目的 最近,肿瘤起始细胞已经被认为与肿瘤形成、肿瘤耐药和肿瘤复发密切相关的重要因素.研究肝癌中肿瘤起始细胞与非肿瘤起始细胞的microRNA表达谱的差异,有利于找到与肿瘤起始细胞干性维持相关的关键microRNA,为肿瘤起始细胞靶向治疗提供依据.方法 本课题组前期已经从肝癌 Huh7细胞中分离鉴定了肿瘤起始细胞(CD 133+EpCAM+亚群)和非肿瘤起始细胞(CD 133-EpCAM-亚群),运
会议
大黄酸是中药大黄根茎中的蒽醌类化合物之一,具有抗肿瘤、抗炎、泻下和健胃等药理作用.研究表明大黄酸能够抑制肿瘤细胞增殖、促进肿瘤细胞凋亡、并能增加其它抗肿瘤药物的疗效.遗憾的是大黄酸难溶于水,这就限制了其应用.本课题组将大黄酸与赖氨酸在特定条件下反应,得到了能溶于水的赖氨大黄酸盐.我们前期研究发现赖氨大黄酸能诱导MCF-7、HELA、HEPG2和A549细胞的细胞质中出现大量空泡,而未见于小鼠原代肝
会议
目的 表皮生长因子受体(EGFR)家族(包括EGFR、HER2、HER3、HER4)广泛存在于体内各种细胞中,其异常活化与多种人类上皮瘤的发生、发展密切相关,因此它已成为肿瘤治疗中重要的靶点之一.靶向EGFR家族的药物在近10年以来作为肿瘤治疗的新方案而被广泛地研究,特别是单克隆抗体类药物.其中,靶向HER2的trastuzumab在临床上已被广泛的应用于治疗转移性乳腺癌.但是越来越多的临床资料表
氨肽酶N(Aminopeptidase N,APN)又称CD13,是一种多功能的膜结合金属蛋白酶,多年来用于对白血病或淋巴瘤细胞的定性和分型.CD13是新生血管形成过程中的一个重要调节分子,在肿瘤新生血管内皮细胞上特异性高表达.随着对CD13研究的不断深入,越来越多的证据表明,CD13在乳腺癌、肝癌和结肠癌等多种癌细胞表面高表达,还可作为肝癌干细胞的表面标志物,与肿瘤的发生发展、侵袭转移和预后密切
会议
Curcumin,the yellow pigment present in the Indian spice turmeric derived from Curcuma longa,associated with curry powder.Curcumin is a well-established natural antioxidant,antitumor and anti-inflammat
AIM Our present study aimed to test the anti-cancer effect of natural product ZX-1201 on pancreatic cancer cell PANC-1.METHODS After incubation with different concentrations of drug or vehicle,PANC-1
Background Radiotherapy and adjuvant eisplatin chemotherapy are the mainstream approaches in the treatment of nasopharyngeal carcinoma (NPC).However,chemotherapy resistance in the course of treatment
Objective To investigate the relationship between SNP (Single nucleotide polymorphisms)in MDM2(Murine double minute 2) and the susceptibility and biological behavior of hepatocellular carcinoma.Method
Background & Aims BRCA1 expression affects outcome to chemotherapy.In response DSBs,MDC1 binds to H2AX,promoting DSB repair by 53BP1 and BRCA1.MMSET is required for the accretion of 53BP1 and UBC9 to
会议
Objective To investigate the effects of the effective parts of Salvia chinensis of the biological behaviors of vascular endothelial cells Methods Human umbilical vein endothelial cells (HUVECs) were c