【摘 要】
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Previous studies indicate that the Nrf2-ARE signaling pathway plays a neruo-protective role in glia cell, however, the mechanism was also elusive.This study aims to explore the inhibitive function of
【机 构】
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The Second Affiliated Hospital of Nanchang University
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Previous studies indicate that the Nrf2-ARE signaling pathway plays a neruo-protective role in glia cell, however, the mechanism was also elusive.This study aims to explore the inhibitive function of all-trans-retinoic (ATRA) on Nrf2-ARE pathway in intracerebral hemorrhage (ICH), and investigate the mechanism.In this study, the femoral artery injection method was employed to establish ICH model.The model rats were randomly divided into four groups, including Sham group, ICH group,ATRA group and DMSO group.The neurological scores were evaluated for the four groups at different time points.Hematoxylin-Eosin staining was used to stain the CD11b positive glia cells.
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