【摘 要】
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In asymmetric catalysis with organometallic complexes, chiral ligands generally play critical and irreplaceable role in enantioselective transformations.Thus th
【机 构】
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KeyLaboratoryofOrganosiliconChemistryandMaterialTechnologyofMinistryofEducation,HangzhouNormalUniver
【出 处】
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中国化学会第六届全国分子手性学术研讨会
论文部分内容阅读
In asymmetric catalysis with organometallic complexes, chiral ligands generally play critical and irreplaceable role in enantioselective transformations.Thus the rational design and synthesis of efficient chiral ligands for enantioselective metal-catalyzed reactions that provide facile access to optically pure compounds is very important.1 Recently, we have developed a practical methodology for the preparation of an interesting type of chiral diols with multi-stereogenic centers,Ar-BINMOLs, in which the simple axial chiral monoalkylated BINOLs could be converted into optically pure 1,1 -binaphthalene-2-o-arylmethanol-2-ols (Ar-BINMOLs) with axial and sp3-central chirality through asymmetric [1,2]-Wittig rearrangement.2 Over the past years, they have been proved to be attractive chiral ligands in several enantioselective transformations.3 On the basis of the previous findings, we have successfully continued the design and synthesis of a family of Ar-BINMOL-based P-ligands endowed with axial and sp3-central chirality, which exhibited excellent enantioselectivity in several organic transformations.4
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