【摘 要】
：
Thrombotic disease.caused by thrombosis and thromboembolism,is seriously harmful to human health and is one of the major causes of death in modern society.B
【机 构】
：
DepartmentofFoodScienccandEngineering,HarbinInstituteofTechnologyHarbin150090,ChinaSchoolorFoodScicn
【出 处】
：
第八届国际分子模拟与信息技术应用学术会议
论文部分内容阅读
Thrombotic disease.caused by thrombosis and thromboembolism,is seriously harmful to human health and is one of the major causes of death in modern society.Blood clotting can be prevented by anticoagulant drugs by influencing some impact factors in the blood coagulation process.Food-derived biological peptides with anticoagulant activity have many advantages.such as fast absorption and low side effects.which are attracting more and more attentions on anticoagulants studies.Casein is a good source of bioactive peptides.In the present study,αs1-,αs2-,β-and κ-casein were selected for in silico digestion,and the theoretic peptides from them were predicted.Antithrombotic peptides from αs1-,αs2-,β-and κ-casein were screened by bioinformatics analysis based on the amino acid sequences of antithrombotic peptides reported.Molecular docking.using Accelrys Discovery Studio software.was adopted to confirm some new anticoagulant peptides.One peptide from αs2-casein,Ser-Ser-Glu-Glu-Ser-Ile-Ile-Ser-Gln-Glu-Thr-Tyr-Lys-Gln-Glu-Lys-Asn-Met-Asp.showed better affinity activity with thrombin based on the results of bioinformatics analysis.The result from this study could provide some theoretical information for the application of antithrombotic peptides in functional food industry especially in dairy nutrition.
其他文献
Three alkali metal lead orthophosphates,APbPO4(A = K,Rb,Cs),have been synthesized by conventional solid-state reaction.The single-crystal X-ray structural a
Compounds containing both B–O and P–O groups are of wide interest and have been classified into borophosphates and borate–phosphates by R.Kniep et al.In
Exploring chromophores which determine band gap sizes and nonlinear optical(NLO)activity is of importance for material design.In this study,the electronic s
Phosphates with noncentrosymmetric(NCS)structures usually display short ultraviolet(UV)cut-off edges,but often exhibit weak powder second harmonic generatio
A series of alkali metal magnesium tungstates,A4Mg(WO4)3(A = Na,K),R2Mg2(WO4)3(R = Rb,Cs),were synthesized from a high temperature solution,and their struct
Introducing NO3 groups or some rare-earth metals is one strategy to obtain potential optical functional materials without influencing the transmittance in u
The first mixed-anion transition metal(TM)fluoride with [MF6]x-(M = TM cation)anion group,Na3NH4(TiF6)(SO4)·H2O(NTS),was synthesized by a facile hydrotherm
In this research work,Ag-containing quaternary-chalcogenide compounds KAg2TS4(T=P,Sb)(Ⅰ-Ⅱ)and RbAg2SbS4(Ⅲ)have been studied by means of Density Functiona
The perovskite structure is a good candidate for the design of functional materials.On the basis of the combination of B6O13 groups and XM6(X = Cl,Br; M = a
With the introduction of an alkali metal into the B- O framework,two new alkali metal borate crystals,Li5Cs2B7O14 and Li4CsB5O10,have been obtained for the