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A web-based modeling platform is developed.We will show on this platform our continuum(or implicit solvent)molecular modeling approaches in computations of molecular surface mesh,Poisson-Boltzmann electrostatic solvation energy,ion transport property of ion channels/nanopores,reaction rate of diffusion-controlled substrate-enzyme reaction.In particular,one application is to study the ion current signals of a DNA-nanopore system which is a potential technology for next generation of gen sequencing.Another application is to study the effect of charged substrate and product species to their diffusion-controlled binging rate.