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目的观察沙丁胺醇联合异丙托溴铵在改善早产儿呼吸系统疾病的疗效,为临床诊治提供参考依据。方法将112例早产肺类或呼吸窘迫征患儿随机分为治疗组、对照组,治疗组在常规治疗的基础上,入院后给予沙丁胺醇和异丙托溴铵雾化吸入,对照组仅给予常规治疗。结果治疗组发生呼吸困难、低氧血症、外周给氧、呼吸暂停、单纯血氧饱和度下滑情况与对照组相比,差异均无统计学意义(P>0.05);治疗组呼吸困难缓解时间、低氧血症纠正时间、外周给氧时间、呼吸暂停缓解时间、单纯血氧饱和度下滑缓解时间与对照组相比,差异均有统计学意义(P<0.05),且治疗组症状和体征缓解时间均短于对照组。结论沙丁胺醇联合异丙托溴铵雾化吸入治疗早产儿呼吸系统疾病,不能减少其呼吸困难、低氧血症、呼吸暂停等症状和体征的发生,不能避免外周给氧,但能改善症状,缩短给氧时间,缩短病程。
Objective To observe the curative effect of albuterol and ipratropium bromide on respiratory diseases in premature infants and provide a reference for clinical diagnosis and treatment. Methods 112 cases of preterm birth pulmonary or respiratory distress syndrome were randomly divided into treatment group, control group, treatment group on the basis of routine treatment, after admission to salbutamol and ipratropium bromide inhalation, the control group was given only routine treatment. Results There was no significant difference between the treatment group and the control group in dyspnea, hypoxemia, peripheral oxygen supply, apnea, and simple oxygen saturation decline (P> 0.05). The treatment group had shorter dyspnea time , Time of correction of hypoxemia, time of peripheral oxygen administration, time of apnea relief, and the decline of pure oxygen saturation were significantly different from those of the control group (P <0.05), and the symptoms and signs of the treatment group The remission time was shorter than the control group. Conclusion Salbutamol combined with ipratropium bromide inhalation for the treatment of respiratory diseases in preterm infants can not reduce the occurrence of symptoms such as dyspnea, hypoxemia, apnea and other symptoms and signs, and can not avoid the peripheral oxygen supply, but can improve symptoms and shorten Oxygen time, shorten the course of the disease.