论文部分内容阅读
Deep brain stimulation (DBS) of the different target sites in the basal ganglia has recently been recognized as the most effective neurosurgical therapy for hypokinesia with Parkinsons disease,but the mechanism underlying its curative effect remains unknown.Basal ganglia contains two principal pathways: the direct and indirect pathways,which are two major components of Cortico-basal-thalamic loop.Using a computational model,We investigates the different circuit effects of deep brain stimulation (DBS) for Parkinson’s disease (PD) in different target sites in the subthalamic nucleus (STN),the internal segment of the globus pallidus (GPi),and the external segment of the globus pallidus (GPe),and two pathways have opposite effects on motor activity through comparative analysis.Our results suggest that DBS in the STN could functionally repair the TC relay activity,while DBS in the GPe and in the GPi could functionally over-activate and inhibit it,respectively,which are consistent with the experimental and the clinical evidences on the network effects of DBS,and the direct pathway turns up motor activity,which in turn,the indirect pathway turns down motor activity.