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Natural products invariably show a broad range of interesting and useful biological activities.Most of successful drug and pesticide are analogs of natural products.These analogs are valuable since they could give rise to novel and simplified structures with improved biological activities,new modes of action,and increased safety towards humans,plants,animals and the environment.Consequently,natural product-like compounds are ideal for identification of new lead molecules with useful functionalities.However,structural optimization of natural products could still be a formidable challenge due to their inherent structural complexity.